In contrast, the prothrombin time (PT), another non-specific coagulation test, is normally unaffected by lupus anticoagulant. Workup Īn aPTT is generally included in a differential diagnosis in vague symptoms, and is a non-specific test of coagulation. Testing for lupus anticoagulant can also be indicated by a prolonged aPTT test that is unexplained. thrombosis or pregnancy complication) and two positive blood test results spaced at least three months apart that detect at least one of the three types of antibodies. In a suspected antiphospholipid syndrome, lupus anticoagulant is generally tested in conjunction with anti-apolipoprotein antibodies and anti-cardiolipin antibodies, and diagnostic criteria require one clinical event (i.e. The main indication for testing for lupus anticoagulant is a suspected antiphospholipid syndrome, whose main manifestations are blood clots ( thrombosis) in both arteries and veins as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery, and severe preeclampsia. However in vivo, it functions as a procoagulant. The term "anticoagulant" accurately describes its function in vitro.People with lupus erythematosus are more likely to develop a lupus anticoagulant than the general population. Most patients with a lupus anticoagulant do not actually have lupus erythematosus, and only a small proportion will proceed to develop this disease (which causes joint pains, skin problems and kidney failure, amongst other complications).Both words in the term "lupus anticoagulant" can be misleading:
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |